Article
Integrated "omics" profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus.
BMC genomics - 10 Apr 2013
Durban Jordi, Pérez Alicia, Sanz Libia, Gómez Aarón, Bonilla Fabián, Rodríguez Santos, Chacón Danilo, Sasa Mahmood, Angulo Yamileth, Gutiérrez José M, Calvete Juan J
Abstract excerpt
BACKGROUND: Understanding the processes that drive the evolution of snake venom is a topic of great research interest in molecular and evolutionary toxinology. Recent studies suggest that ontogenetic changes in venom composition are genetically controlled rather than environmentally induced. However, the molecular mechanisms underlying these changes remain elusive. Here we have explored the basis and level of...
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