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Article

Interisland mutation of a novel phospholipase A2 from Trimeresurus flavoviridis venom and evolution of Crotalinae group II phospholipases A2.

Journal of molecular evolution - 1 Nov 2003

Chijiwa Takahito, Hamai Sachiko, Tsubouchi Shoji, Ogawa Tomohisa, Deshimaru Masanobu, Oda-Ueda Naoko, Hattori Shosaku, Kihara Hiroshi, Tsunasawa Susumu, Ohno Motonori

Abstract excerpt

Trimeresurus flavoviridis (Crotalinae) snakes inhabit the southwestern islands of Japan: Amami-Oshima, Tokunoshima, and Okinawa. Affinity and conventional chromatographies of Amami-Oshima T. flavoviridis venom led to isolation of a novel phospholipase A2 (PLA2). This protein was highly homologous (91%) in sequence to trimucrotoxin, a neurotoxic PLA2, which had been isolated from T. mucrosquamatus (Taiwan) venom,...

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PMID: 14738313
DOI: 10.1007/s00239-003-2508-4

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