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Article

Amyloidosis in familial Mediterranean fever patients: correlation with MEFV genotype and SAA1 and MICA polymorphisms effects.

BMC medical genetics - 10 Feb 2004

Medlej-Hashim Myrna, Delague Valérie, Chouery Eliane, Salem Nabiha, Rawashdeh Mohammed, Lefranc Gérard, Loiselet Jacques, Mégarbané André

Abstract excerpt

BACKGROUND: Familial mediterranean fever (FMF) is a recessively inherited disease characterized by recurrent crises of fever, abdominal, articular and/or thoracic pain. The most severe complication is the development of renal amyloidosis. Over 35 mutations have been discovered so far in the gene responsible for the disease, MEFV. This article aims at determining a correlation between the MEFV genotype and the...

Topics

Adolescent
Adult
Alleles
Amyloidosis
Child
Child, Preschool
Cytoskeletal Proteins
Familial Mediterranean Fever
Gene Frequency
Genotype
Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Mutation

Polymorphism, Genetic

Proteins

Pyrin

Serum Amyloid A Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 15018633
DOI: 10.1186/1471-2350-5-4
PMCID: PMC356915

Genes

MICA
SAA1
MEFV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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