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Article

Spacers increase the accessibility of peptide ligands linked to the carboxyl terminus of adenovirus minor capsid protein IX.

Journal of virology - 1 Apr 2004

Vellinga Jort, Rabelink Martijn J W E, Cramer Steve J, van den Wollenberg Diana J M, Van der Meulen Hans, Leppard Keith N, Fallaux Frits J, Hoeben Rob C

Abstract excerpt

The efficiency and specificity of gene transfer with human adenovirus (hAd)-derived gene transfer vectors would be improved if the native viral tropism could be modified. Here, we demonstrate that the minor capsid protein IX (pIX), which is present in 240 copies in the Ad capsid, can be exploited as an anchor for heterologous polypeptides. Protein IX-deleted hAd5 vectors were propagated in hAd5 helper cells...

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Share to Adenoviridae
Share to Capsid Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microscopy, Immunoelectron

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Source

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Identifiers

PMID: 15016870
DOI: 10.1128/jvi.78.7.3470-3479.2004
PMCID: PMC371045

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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