Article
YY1 transcription factor is not responsible for the negative regulation of hamster Muc1 transcription.
Anticancer research - 1 Jan 2000
Hisatsune Akinori, Hyun Sang Won, Lee Insong James, Georas Steven, Kim K Chul
Abstract excerpt
Muc1 is the cell surface glycoprotein abundantly expressed in cancer cells and has been shown to be involved in tumor metastasis and promotion. Recently, we identified a 37 bp segment on the hamster Muc1 promoter with the ability to suppress Muc1 transcription. This 37 bp putative negative regulatory element (NRE) binds to a transcriptional regulator Yin Yang 1 (YY1). In the present study, we examined whether...
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