Article
Brca2 is involved in meiosis in Arabidopsis thaliana as suggested by its interaction with Dmc1.
The EMBO journal - 24 Mar 2004
Siaud Nicolas, Dray Eloïse, Gy Isabelle, Gérard Emmanuelle, Takvorian Najat, Doutriaux Marie-Pascale
Abstract excerpt
Two BRCA2-like sequences are present in the Arabidopsis genome. Both genes are expressed in flower buds and encode nearly identical proteins, which contain four BRC motifs. In a yeast two-hybrid assay, the Arabidopsis Brca2 proteins interact with Rad51 and Dmc1. RNAi constructs aimed at silencing the BRCA2 genes at meiosis triggered a reproducible sterility phenotype, which was associated with dramatic meiosis...
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