Article
The beta-thalassemia mutation/haplotype distribution in the moroccan population.
Hemoglobin - 1 Feb 2004
Lemsaddek Wafaâ, Picanço Isabel, Seuanes Filomena, Nogueira Paulo, Mahmal Lahoucine, Benchekroun Saâd, Khattab Mohammed, Osório-Almeida Leonor
Abstract excerpt
The present study compiles the results of our own research and of a prior study on beta-thalassemia (thal) in Morocco, comprising a total of 187 beta-thalassemic chromosomes. Six major mutations: (beta0) codon 39 (C --> T), (beta+) IVS-I-6 (T --> C), (beta0) frameshift codon (FSC) 6 (-A), (beta0) FSC 8 (-AA), (beta0) IVS-I-1 (G --> A) and (beta+) -29 (A --> G) account for 75.7% of the independent chromosomes...
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