Article
Genotypic correlation between six common beta-thalassemia mutations and the XmnI polymorphism in the Moroccan population.
Hemoglobin - 1 Jan 2007
Agouti Imane, Badens Catherine, Abouyoub Ahmed, Khattab Mohamed, Sayah Fouad, Barakat Amina, Bennani Mohcine
Abstract excerpt
beta-Thalassemia (thal) is the most common recessive inherited disorder in Mediterranean populations. It is estimated that the frequency of this disease in the Moroccan population is between 1.5 and 3.0%. Severe forms of homozygous thalassemia cases require expensive and technically demanding curative (bone marrow transplantation) or palliative (chronic transfusion/chelation) therapies. The -158 (C-->T)...
Topics
- DNA
- DNA Primers
- Deoxyribonucleases, Type II Site-Specific
- Humans
- Incidence
- Morocco
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Restriction Mapping