Sampling genotypes on complex pedigrees with phenotypic constraints: the origin of the B allele among the Polar Eskimos.

doi:10.1093/imammb/9.1.1

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Article

Sampling genotypes on complex pedigrees with phenotypic constraints: the origin of the B allele among the Polar Eskimos.

IMA journal of mathematics applied in medicine and biology - 1 Jan 1992

Sheehan N

Abstract excerpt

Exact probability calculations are often infeasible on large complex pedigrees. Conditional independences, however, occurring as a natural consequence of Mendelian inheritance of genetic traits, define a locally dependent Markov random field on the state space of all genotypic configurations on t...

Topics

ABO Blood-Group System
Alleles
Genotype
Inuit
Markov Chains
Pedigree
Phenotype

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