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Article

The recombinant major allergen of <i>Parietaria judaica</i> and its hypoallergenic variant: <i>in vivo</i> evaluation in a murine model of allergic sensitization

1 Mar 2004

Abstract excerpt

BACKGROUND: Par j 1 represents the major allergenic component of Parietaria judaica pollen. Its three-dimensional structure is stabilized by four disulphide bridges. A family of three-dimensional mutants of the recombinant Par j 1 (rPar j 1) allergen, showing reduced allergenicity and retained T cell recognition has been recently developed by site-directed mutagenesis. OBJECTIVE: To develop and characterize a...

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Identifiers

PMID: 15005743
DOI: 10.1111/j.1365-2222.2004.01894.x

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