Article
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.
The Journal of biological chemistry - 21 May 2004
Galigniana Mario D, Harrell Jennifer M, O'Hagen Heather M, Ljungman Mats, Pratt William B
Abstract excerpt
The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein. However, the connection between p53 and the dynein motor protein complex has not been established. Here, we show that hsp90.binding immunophilins link p53.hsp90 complexes to dynein and that prevention of that linkage in vivo inhibits the nuclear movement of p53. First, we show that p53.hsp90...
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