Article
The membrane-proximal tryptophan-rich region in the transmembrane glycoprotein ectodomain of feline immunodeficiency virus is important for cell entry.
Virology - 1 Mar 2004
Giannecchini Simone, Bonci Francesca, Pistello Mauro, Matteucci Donatella, Sichi Olimpia, Rovero Paolo, Bendinelli Mauro
Abstract excerpt
The mechanisms whereby feline immunodeficiency virus (FIV) adsorbs and enters into susceptible cells are poorly understood. Here, we investigated the role exerted in such functions by the tryptophan (Trp)-rich motif present membrane-proximally in the ectodomain of the FIV transmembrane glycoprotein. Starting from p34TF10, which encodes the entire genome of FIV Petaluma, we produced 11 mutated clones having the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.