Cell Shape Normalization, Dendrite Orientation, and Melanin Production of Normal and Genetically Altered (Haploinsufficient NF1)‐Melanocytes by Microstructured Substrate Interactions

doi:10.1002/cphc.200300868

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Article

Cell Shape Normalization, Dendrite Orientation, and Melanin Production of Normal and Genetically Altered (Haploinsufficient NF1)‐Melanocytes by Microstructured Substrate Interactions

19 Jan 2004

Abstract excerpt

Little is known about how functional regulation failure in genetically altered cells is influenced by topographical confinement of cells, a situation often present in tissues in vivo. We used cultured melanocytes derived from human skin samples as a model system for such investigations. Normal melanocytes have a very well defined shape consisting of a cell body and two dendrites arranged 180 degrees relative to...

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PMID: 14999847
DOI: 10.1002/cphc.200300868

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