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Article

Protein profiling and identification of modulators regulated by the E7 oncogene in the C33A cell line by proteomics and genomics

19 Feb 2004

Abstract excerpt

Human papillomaviruses (HPVs) have been recognized as the primary cause of cervical cancer. HPV 16 E7 binds to tumor suppressor retinoblastoma protein, and interferes with its function, causing release of the transcription factor E2F, which influences expression of cell cycle-related genes. This study was performed to identify the genes and proteins modulated by the HPV E7 oncogene. An HPV-negative cervical...

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PMID: 14997504
DOI: 10.1002/pmic.200300626

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