Article
Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk.
Molecular carcinogenesis - 1 Mar 2004
Rusin Marek, Zientek Helena, Krześniak Małgorzata, Małusecka Ewa, Zborek Anna, Krzyzowska-Gruca Stefania, Butkiewicz Dorota, Vaitiekunaite Rasa, Lisowska Katarzyna, Grzybowska Ewa, Krawczyk Zdzisław
Abstract excerpt
Somatic mutations of 11q23.3-linked constitutive heat shock protein 70 gene (HSPA8 alias HSC70) are detected by others in breast carcinomas. To examine whether intragenic, somatic mutations of HSPA8 occur in lung carcinomas, we sequenced its exons 2-8, with adjacent intronic sequences, in a series of DNA samples from non-small-cell lung cancers (NSCLC). Twenty-one polymorphisms were detected, but no somatic...
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