Article
Optimisations and Challenges Involved in the Creation of Various Bioluminescent and Fluorescent Influenza A Virus Strains for In Vitro and In Vivo Applications.
PloS one - 1 Jan 2015
Spronken Monique I, Short Kirsty R, Herfst Sander, Bestebroer Theo M, Vaes Vincent P, van der Hoeven Barbara, Koster Abraham J, Kremers Gert-Jan, Scott Dana P, Gultyaev Alexander P, Sorell Erin M, de Graaf Miranda, Bárcena Montserrat, Rimmelzwaan Guus F, Fouchier Ron A
Abstract excerpt
Bioluminescent and fluorescent influenza A viruses offer new opportunities to study influenza virus replication, tropism and pathogenesis. To date, several influenza A reporter viruses have been described. These strategies typically focused on a single reporter gene (either bioluminescent or fluorescent) in a single virus backbone. However, whilst bioluminescence is suited to in vivo imaging, fluorescent viruses...
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