Article
Inbred FVB/N mice are mutant at the cp49/Bfsp2 locus and lack beaded filament proteins in the lens.
Investigative ophthalmology & visual science - 1 Nov 2006
Simirskii Vladimir N, Lee Robert S, Wawrousek Eric F, Duncan Melinda K
Abstract excerpt
PURPOSE: FVB/N is considered an ideal inbred mouse strain for transgenic mouse production because of the ease of pronuclear microinjection and its overall fecundity. It is well established that vertebrate lens fiber cells normally express a modified intermediate filament network consisting of the proteins filensin and CP49, and it was recently reported that the mouse strain 129 harbors mutations in CP49 that have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.