Article
Transcriptional regulation of the Drosophila catalase gene by the DRE/DREF system.
Nucleic acids research - 1 Jan 2004
Park So Young, Kim Young-Shin, Yang Dong-Jin, Yoo Mi-Ae
Abstract excerpt
Reactive oxygen species (ROS) cause oxidative stress and aging. The catalase gene is a key component of the cellular antioxidant defense network. However, the molecular mechanisms that regulate catalase gene expression are poorly understood. In this study, we have identified a DNA replication-related element (DRE; 5'-TATCGATA) in the 5'-flanking region of the Drosophila catalase gene. Gel mobility shift assays...
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