Article
Disorganization is a completely dominant gain-of-function mouse mutation causing sporadic developmental defects.
Mechanisms of development - 1 May 1992
Crosby J L, Varnum D S, Washburn L L, Nadeau J H
Abstract excerpt
Disorganization (Ds) is an exceptional mutation because of its diverse and profound developmental effects. Although other mouse mutations produce similar congenital defects, extreme pleiotropism, random occurrence, developmental independence of multiple defects, and type of anomaly make Ds unique. Examples of developmental defects include cranioschisis, rachischisis, thoracoschisis, exencephaly, hamartomas, and...
Topics
- Abnormalities, Multiple
- Animals
- Congenital Abnormalities
- Crosses, Genetic
- Embryonic and Fetal Development
- Genes, Dominant
- Genetic Markers
- Genotype
- Humans
- Incidence
- Mice