Two-hit model for sporadic congenital anomalies in mice with the disorganization mutation.

Abstract excerpt

Congenital anomalies have complex etiologies involving both genetic and nongenetic components. Many are sporadic, without obvious evidence for heritability. An important model for these anomalies is a mutation in laboratory mice that is called "disorganization" (Ds), which functions as a variable...

Topics

• Abnormalities, Multiple
• Animals
• Chi-Square Distribution
• Chromosome Aberrations
• Chromosome Disorders
• Disease Models, Animal
• Gene Expression
• Genes, Dominant
• Mice
• Mice, Inbred Strains
• Mice, Mutant Strains
• Models, Genetic
• Mutation
• Poisson Distribution