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Article

Alteration in α‐synuclein mRNA expression in Parkinson's disease

19 Nov 2003

Abstract excerpt

The presynaptic protein alpha-synuclein is considered to play an important role in the pathophysiology of Parkinson's disease (PD). Point mutations in the alpha-synuclein gene have been demonstrated in familial PD and alpha-synuclein is a major component of Lewy bodies, the pathological hallmark of the sporadic disease. It is not clear whether abnormal accumulation of alpha-synuclein is the result of abnormal...

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PMID: 14978671
DOI: 10.1002/mds.10683

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