Article
Genetic analyses of longitudinal phenotype data: a comparison of univariate methods and a multivariate approach.
BMC genetics - 31 Dec 2003
Yang Qiong, Chazaro Irmarie, Cui Jing, Guo Chao-Yu, Demissie Serkalem, Larson Martin, Atwood Larry D, Cupples L Adrienne, DeStefano Anita L
Abstract excerpt
BACKGROUND: We explored three approaches to heritability and linkage analyses of longitudinal total cholesterol levels (CHOL) in the Genetic Analysis Workshop 13 simulated data without knowing the answers. The first two were univariate approaches and used 1) baseline measure at exam one or 2) summary measures such as mean and slope from multiple exams. The third method was a multivariate approach that directly...
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