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Article

Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants.

The Journal of biological chemistry - 30 Apr 2004

Kanekura Kohsuke, Hashimoto Yuichi, Niikura Takako, Aiso Sadakazu, Matsuoka Masaaki, Nishimoto Ikuo

Abstract excerpt

Mutation of the ALS2 gene encoding alsin is linked to the onset of autosomal recessive motor neuron diseases, including juvenile-onset amyotrophic lateral sclerosis (ALS). Alsin long form (LF) belongs to the family of the guanine nucleotide exchanging factor (GEF) for small GTPases. Expression of...

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Source

Identifiers

PMID: 14970233
DOI: 10.1074/jbc.M313236200

Genes

SOD1
ALS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14970233-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants.PMID 14970233Read ↗

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