Article
Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc.
Molecular endocrinology (Baltimore, Md.) - 1 May 2004
Barletta Frank, Wong Chi-Wai, McNally Chris, Komm Barry S, Katzenellenbogen Benita, Cheskis Boris J
Abstract excerpt
In this study, we have evaluated the molecular mechanism of Src activation after its interaction with estrogen receptor alpha (ERalpha) and a newly identified scaffold protein, called MNAR (modulator of nongenomic activity of ER). Under basal condition, Src enzymatic activity is inhibited by intramolecular interactions. The enzyme can be activated by interaction between the SH2 domain of Src and...
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