Article
In psoriasis lesional skin the type I interferon signaling pathway is activated, whereas interferon-alpha sensitivity is unaltered.
The Journal of investigative dermatology - 1 Jan 2004
van der Fits Leslie, van der Wel Leontine I, Laman Jon D, Prens Errol P, Verschuren Martie C M
Abstract excerpt
The epidermal phenotype as observed in psoriatic skin results from inflammation and abnormal proliferation and terminal differentiation of keratinocytes. Mice deficient for interferon regulatory factor-2, a repressor of interferon signaling, display psoriasis-like skin inflammation. The development of this phenotype is strictly dependent on type I interferon (interferon-alpha/beta) signaling. The aim of this...
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