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Article

Beta thalassaemia in the indigenous British population.

British journal of haematology - 1 Nov 1992

Hall G W, Barnetson R A, Thein S L

Abstract excerpt

We have analysed the molecular basis of beta-thalassaemia in 22 Anglo-Saxon individuals, all of whom were heterozygous for beta-thalassaemia except for one, who was a compound heterozygote. Using a combination of allele-specific priming of the polymerase chain reaction (PCR) and direct sequencing of genomic DNA amplified by the PCR, 20/23 beta-thalassaemic genes were characterized. Nine different mutations were...

Topics

Base Sequence
Codon
Genotype
Globins
Haplotypes
Humans
Molecular Sequence Data
Mutation
Phenotype
United Kingdom
beta-Thalassemia

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Identifiers

PMID: 1486039
DOI: 10.1111/j.1365-2141.1992.tb06471.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1486039-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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