Article
Changing issues of quality control: diploid and non-diploid cell lines.
Developments in biological standardization - 1 Jan 1992
Pearson J
Abstract excerpt
Early viral vaccines were prepared from primary monkey kidney cell cultures. However, primary cell cultures can be highly variable and also present a risk of contamination by endogenous viruses. The development of human diploid cell lines for vaccine production provide greater assurance of consistency and freedom from contaminating viruses. Continuous cell lines present considerable advantages in the preparation...
Topics
- Animals
- Biological Products
- Cell Line
- Diploidy
- Genotype
- Humans
- Phenotype
- Quality Control
- Viral Vaccines