Article
Expression of the glucose transporter gene, ptsG, is regulated at the mRNA degradation step in response to glycolytic flux in Escherichia coli.
The EMBO journal - 2 Jul 2001
Kimata K, Tanaka Y, Inada T, Aiba H
Abstract excerpt
We report a novel post-transcriptional control of the ptsG gene encoding the major glucose transporter IICB(Glc). We demonstrate that the level of IICB(Glc) is markedly reduced when the glycolytic pathway is blocked by a mutation in either the pgi or pfkA gene encoding phosphoglucose isomerase or phosphofructokinase, respectively. This down-regulation of ptsG is not exerted at the transcriptional level. Both...
Topics
- Citric Acid Cycle
- Endoribonucleases
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Enzymologic
- Genotype
- Glucose
- Glycolysis
- Lac Operon
- Methylglucosides
- Phosphoenolpyruvate Sugar Phosphotransferase System
- RNA, Messenger