Article
[Determination of autoantibody for myelin antigens in the serum of patients HLA-DQB1*0602 with multiple sclerosis].
Arquivos de neuro-psiquiatria - 1 Dec 2003
Carvalho Adriana, Sant'anna Gabriele, Santos Cláudio Cirne, Frugulhetti Izabel Palmer, Leon Soniza Alves, Quírico-Santos Thereza
Abstract excerpt
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the human central nervous system (CNS) mediated by autoimmune Th1 lymphocytes. We determined the serum levels of autoantibodies for myelin basic protein (MBP), proteolipid (PLP) and myelin oligodendrocyte glycoprotein sequence MOG 92-106 in a group of 54 healthy individuals and 26 MS patients expressing or not HLA-DQB1*0602. Regardless...
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