Binding of destabilized betaB2-crystallin mutants to alpha-crystallin: the role of a folding intermediate.

Abstract excerpt

Age-related changes in protein-protein interactions in the lens play a critical role in the temporal evolution of its optical properties. In the relatively non-regenerating environment of the fiber cells, a critical determinant of these interactions is partial or global unfolding as a consequence of post-translational modifications or chemical damage to individual crystallins. One type of attractive force...

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