Article
Surveillance for familial pancreatic cancer.
Scandinavian journal of gastroenterology. Supplement - 1 Jan 2003
de Vos tot Nederveen Cappel W H, Lagendijk M A C, Lamers C B H W, Morreau H, Vasen H F A
Abstract excerpt
BACKGROUND: It is estimated that between 5% and 10% of pancreatic cancer (PC) cases are due to hereditary factors. METHODS: Review of the literature. RESULTS: In families with clustering of PC, germline mutations in specific genes might be responsible for the disease. It is suggested that PC progresses from precursor lesions, the pancreatic intraepithelial neoplasias (PanINs). Several key genetic alterations in...
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