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Article

Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor.

Nucleic acids research - 23 Jan 2004

Watterson James H, Raha Sandeep, Kotoris Christopher C, Wust Christopher C, Gharabaghi Farhad, Jantzi Sarah C, Haynes Nicole K, Gendron Nathalie H, Krull Ulrich J, Mackenzie Alex E, Piunno Paul A E

Abstract excerpt

Rapid (<2 min) and quantitative genotyping for single nucleotide polymorphisms (SNPs) associated with spinal muscular atrophy was done using a reusable (approximately 80 cycles of application) fibre-optic biosensor over a clinically relevant range (0-4 gene copies). Sensors were functionalized with oligonucleotide probes immobilized at high density (approximately 7 pmol/cm2) to impart enhanced selectivity for SNP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14742865
DOI: 10.1093/nar/gnh013
PMCID: PMC373370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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