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Article

Minimal mutations are required to effect a radical change in function in CEA family members of the Ig superfamily.

Journal of cell science - 15 Feb 2004

Naghibalhossaini Fakhraddin, Stanners Clifford P

Abstract excerpt

GPI anchorage in the CEA family results in the acquisition of radically different functions relative to TM anchorage, including inhibition of differentiation and anoikis, disruption of tissue architecture and promotion of tumorigenicity. CEA GPI anchors, as determined by the carboxy-terminal exon...

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Topics

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Share to Antigens, Differentiation
Share to Carcinoembryonic Antigen
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetulus

Share to Glycosylphosphatidylinositols

Share to Immunoglobulins

Share to Phosphatidylinositol Diacylglycerol-Lyase

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Source

Identifiers

PMID: 14734654
DOI: 10.1242/jcs.00903

Genes

GPI
CEACAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14734654-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Minimal mutations are required to effect a radical change in function in CEA family members of the Ig superfamily.PMID 14734654Read ↗

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