Article
Lamr1 functional retroposon causes right ventricular dysplasia in mice.
Nature genetics - 1 Feb 2004
Asano Yoshihiro, Takashima Seiji, Asakura Masanori, Shintani Yasunori, Liao Yulin, Minamino Tetsuo, Asanuma Hiroshi, Sanada Shoji, Kim Jiyoong, Ogai Akiko, Fukushima Tomi, Oikawa Yumiko, Okazaki Yasushi, Kaneda Yasufumi, Sato Manabu, Miyazaki Jun-ichi, Kitamura Soichiro, Tomoike Hitonobu, Kitakaze Masafumi, Hori Masatsugu
Abstract excerpt
Arrhythmogenic right ventricular dysplasia (ARVD) is a hereditary cardiomyopathy that causes sudden death in the young. We found a line of mice with inherited right ventricular dysplasia (RVD) caused by a mutation of the gene laminin receptor 1 (Lamr1). This locus contained an intron-processed re...
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