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Article

HER-2/neu-Mediated Regulation of Components of the MHC Class I Antigen-Processing Pathway

1 Jan 2004

Abstract excerpt

Because of its amplification and/or overexpression in many human tumors, the HER-2/neu proto-oncogene represents an attractive target for T-cell-mediated vaccination strategies. However, overexpression of oncogenes is often associated with defective expression of components of the MHC class I antigen-processing machinery (APM), thereby resulting in an immune escape phenotype of oncogene-transformed cells. To...

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PMID: 14729627
DOI: 10.1158/0008-5472.can-2522-2

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