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Overexpression of E2F-1 in Lung and Liver Metastases of Human Colon Cancer is Associated with Gene Amplification

1 Apr 2004

Abstract excerpt

We have shown previously that metastatic tumors of human colorectal cancer (CRC) in lung as compared to liver have high levels of thymidylate synthase (TS) mRNA expression correlated with high levels of E2F-1 mRNA expression. We now report that Comparative Genomic Hybridization (CGH) and DNA PCR analyses of lung and liver metastases of human colon cancer show frequent gains in the region of chromosome 20q and...

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PMID: 14726656
DOI: 10.4161/cbt.3.4.733

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