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Article

Impact of aging: sporadic, and genetic risk factors on vulnerability to apoptosis in Alzheimer's disease.

Neuromolecular medicine - 1 Jan 2003

Schindowski Katharina, Kratzsch Tilmann, Peters Jürgen, Steiner Barbara, Leutner Silke, Touchet Natalie, Maurer Konrad, Czech Christian, Pradier Laurent, Frölich Lutz, Müller Walter E, Eckert Anne

Abstract excerpt

The identification of specific genetic (presenilin-1 [PS1] and amyloid precursor protein [APP] mutations) and environmental factors responsible for Alzheimer's disease (AD) has revealed evidence for a shared pathway of neuronal death. Moreover, AD-specific cell defects may be observed in many other nonneuronal cells (e.g., lymphocytes). Thus, lymphocytes may serve as a cellular system in which to study risk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14716024
DOI: 10.1385/NMM:4:3:161

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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