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Chromosome-Encoded Ambler Class D β-Lactamase of<i>Shewanella oneidensis</i>as a Progenitor of Carbapenem-Hydrolyzing Oxacillinase

24 Dec 2003

Abstract excerpt

A chromosome-encoded beta-lactamase gene from a Shewanella oneidensis reference strain was cloned and expressed in Escherichia coli. It encoded a carbapenem-hydrolyzing Ambler class D beta-lactamase, OXA-54, that shared 92% amino acid identity with the plasmid-encoded carbapenem-hydrolyzing oxacillinase OXA-48 from Klebsiella pneumoniae. This work suggests that Shewanella spp. may produce the progenitor of...

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PMID: 14693565
DOI: 10.1128/aac.48.1.348-351.2004

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