Interactions of the QacR Multidrug-Binding Protein with Structurally Diverse Ligands:  Implications for the Evolution of the Binding Pocket

Abstract excerpt

The QacR multidrug-binding repressor protein regulates the expression of the Staphylococcus aureus qacA gene, a multidrug resistance (MDR) locus that is prevalent in clinical isolates of this important human pathogen. In this paper we demonstrate that the range of structurally diverse compounds capable of inducing qacA transcription is significantly more varied than previously appreciated, particularly in...

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