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Article

Functional analyses reveal an important role for tyrosine residues in the staphylococcal multidrug efflux protein QacA.

BMC microbiology - 16 Sept 2008

Wu Jingqin, Hassan Karl A, Skurray Ronald A, Brown Melissa H

Abstract excerpt

BACKGROUND: The staphylococcal QacA multidrug efflux protein confers resistance to an exceptional number of structurally unrelated antimicrobial compounds. Aromatic amino acid residues have been shown to be highly important for the transport function of several multidrug transporters and are intimately involved in multidrug binding. This study investigated the structural and functional importance of the seven...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18793443
DOI: 10.1186/1471-2180-8-147
PMCID: PMC2553796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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