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Article

QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.

Biochemistry - 5 Aug 2008

Peters Kate M, Schuman Jason T, Skurray Ronald A, Brown Melissa H, Brennan Richard G, Schumacher Maria A

Abstract excerpt

The Staphylococcus aureus multidrug binding protein QacR binds to a broad spectrum of structurally dissimilar cationic, lipophilic drugs. Our previous structural analyses suggested that five QacR glutamic acid residues are critical for charge neutralization and specification of certain drugs. For...

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PMID: 18616285
DOI: 10.1021/bi8008246
PMCID: PMC2646753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18616285-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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