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Article

QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.

Biochemistry - 5 Aug 2008

Peters Kate M, Schuman Jason T, Skurray Ronald A, Brown Melissa H, Brennan Richard G, Schumacher Maria A

Abstract excerpt

The Staphylococcus aureus multidrug binding protein QacR binds to a broad spectrum of structurally dissimilar cationic, lipophilic drugs. Our previous structural analyses suggested that five QacR glutamic acid residues are critical for charge neutralization and specification of certain drugs. For example, E57 and E58 interact with berberine and with one of the positively charged moieties of the bivalent drug...

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Identifiers

PMID: 18616285
DOI: 10.1021/bi8008246
PMCID: PMC2646753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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