Article
Ability of pneumococcal serotypes and clones to cause acute otitis media: implications for the prevention of otitis media by conjugate vaccines.
Infection and immunity - 1 Jan 2004
Hanage William P, Auranen Kari, Syrjänen Ritva, Herva Elja, Mäkelä P Helena, Kilpi Terhi, Spratt Brian G
Abstract excerpt
The relative abilities of pneumococcal serotypes and strains (clones) to cause acute otitis media (AOM) were investigated by comparing the serotypes and genotypes of pneumococci recovered from cases of AOM (n = 149) in children <2 years of age with those from nasopharyngeal carriage (n = 288) in age-matched controls from the same region. The odds ratio (OR) for association of pooled vaccine serotypes with AOM was...
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