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Article

Does the Presence of Pneumococcal DNA in Middle‐Ear Fluid Indicate Pneumococcal Etiology in Acute Otitis Media?

23 Feb 2004

Abstract excerpt

Bacterial culture of middle-ear fluid (MEF), the standard for etiologic diagnosis of acute otitis media (AOM), has revealed Streptococcus pneumoniae (Pnc) to be a major pathogen responsible for one-third of AOM cases. In the present study, we compared the results of polymerase chain reaction (PCR) based on the amplification of the pneumolysin gene with the results of pneumococcal culture, for 2595 MEF samples...

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PMID: 14976593
DOI: 10.1086/381765

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