Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adeno-associated Vector Toxicity—To Be or Not to Be?

1 Nov 2015

Abstract excerpt

Vectors based on adeno-associated virus (AAV) are currently in use in numerous gene therapy clinical trials with reports of benefit for patients, for example in treating hemophilia or inherited blindness. An AAV1 vector (Glybera) has recently been approved as the first gene therapy to achieve marketing authorization in Europe. More than 120 clinical trials using AAV have shown vector safety, with a transient and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Viral gastroenteritis research and epidemiology
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26606658
DOI: 10.1038/mt.2015.182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adeno-associated Vector Toxicity—To Be or Not to Be?PMID 26606658Read ↗

Considerations for Preclinical Safety Assessment of Adeno-Associated Virus Gene Therapy ProductsSemantic proximity Read ↗

Strategies to improve safety profile of AAV vectorsSemantic proximity Read ↗

Rationale and strategies for the development of safe and effective optimized AAV vectors for human gene therapySemantic proximity Read ↗

Genotoxicity in Mice Following AAV Gene Delivery: A Safety Concern for Human Gene Therapy?Semantic proximity Read ↗

Development challenges associated with rAAV-based gene therapiesSemantic proximity Read ↗

Emerging Immunogenicity and Genotoxicity Considerations of Adeno-Associated Virus Vector Gene Therapy for HemophiliaSemantic proximity Read ↗

AAV vector manufacturing process design and scalability - Bending the trajectory to address vector-associated immunotoxicitiesSemantic proximity Read ↗

Current and Emerging Issues in Adeno-Associated Virus Vector-Mediated Liver-Directed Gene TherapySemantic proximity Read ↗

Adeno-associated viruses for gene therapy – clinical implications and liver-related complications, a guide for hepatologistsSemantic proximity Read ↗

Next-generation strategies to improve safety and efficacy of adeno-associated virus-based gene therapy for hemophilia: lessons from clinical trials in other gene therapiesSemantic proximity Read ↗

Viral Vectors in Gene Replacement TherapySemantic proximity Read ↗

The intersection of vector biology, gene therapy, and hemophiliaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.