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Article

Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans.

American journal of medical genetics. Part A - 1 Jan 2004

Klootwijk Riko, Groenen Pascal, Schijvenaars Mascha, Hol Frans, Hamel Ben, Straatman Huub, Steegers-Theunissen Régine, Mariman Edwin, Franke Barbara

Abstract excerpt

Neural tube defects (NTD) are congenital malformations arising from incomplete neural tube closure during early embryogenesis. Most NTD in humans show complex inheritance patterns, with both genetic and environmental factors involved in the etiology of this malformation. More than 120 mouse models for human NTD exist. NTD have been observed in mice deficient for the Zic family genes, Zic1, Zic2, and Zic3. We...

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Source

Identifiers

PMID: 14679585
DOI: 10.1002/ajmg.a.20402

Genes

ZIC2
ZIC1
ZIC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans.PMID 14679585Read ↗

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