Article
In vivo expression of B:9-23 peptide/I-A(g7) complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD mice.
Annals of the New York Academy of Sciences - 1 Nov 2003
Abiru Norio, Sun Fuyan, Kawasaki Eiji, Yamasaki Hironori, Oshima Katsuya, Nagayama Yuji, Mizuguchi Hiroyuki, Hayakawa Takao, Miao Dongmei, Liu Edwin, Eisenbarth George S, Eguchi Katsumi
Abstract excerpt
Insulin B chain peptide B:9-23 given to NOD mice decreases the development of diabetes, and phase II trials of an altered peptide ligand of B:9-23 are under way in humans. We have created a gene for the NOD MHC class II beta chain, covalently linked to the B:9-23 peptide. B lymphoma cells transfe...
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