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Influence of CYP2D6 and CYP3A4 Phenotypes, Drug Interactions, and Vitamin D Status on Tamoxifen Biotransformation.

Therapeutic drug monitoring - 1 Dec 2015

Antunes Marina V, Timm Tatiana Aparecida da Fontoura, de Oliveira Vanessa, Staudt Dilana E, Raymundo Suziane, Gössling Gustavo, Biazús Jorge V, Cavalheiro José A, Rosa Daniela D, Wallemacq Pierre, Haufroid Vincent, Linden Rafael, Schwartsmann Gilberto

Abstract excerpt

OBJECTIVE: In view of the large variability on therapeutic response and the multiple factors associated to tamoxifen (TAM) metabolic activation, this study aimed to evaluate the effect of CYP2D6 and CYP3A4 phenotypes, drug interactions, and vitamin D exposure on TAM metabolism in a group of breast cancer patients. METHODS: Trough blood samples were collected from 116 patients. TAM and metabolites endoxifen (EDF),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25853922
DOI: 10.1097/FTD.0000000000000212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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