Article
A CAG repeat polymorphism in the androgen receptor gene is associated with reduced bone mass and increased risk of osteoporotic fractures.
Calcified tissue international - 1 Sept 2003
Langdahl B L, Stenkjaer L, Carstens M, Tofteng C L, Eriksen E F
Abstract excerpt
Osteoporosis is a common disease with a strong genetic component. Hypogonadism results in low bone mass and it increases significantly the risk of osteoporosis in both sexes. The estrogen and androgen receptor genes are therefore strong candidates for mediating the genetic influence on bone mass...
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