Article
Identification and interrogation of highly informative single nucleotide polymorphism sets defined by bacterial multilocus sequence typing databases.
Journal of medical microbiology - 1 Jan 2004
Robertson Gail A, Thiruvenkataswamy Venugopal, Shilling Hayden, Price Erin P, Huygens Flavia, Henskens Frans A, Giffard Philip M
Abstract excerpt
A unified, bioinformatics-driven, single nucleotide polymorphism (SNP)-based approach to microbial genotyping has been developed. Multilocus sequence typing (MLST) databases consist of known variants of standardized housekeeping genes. Normally, seven fragments are defined; a sequence type (ST) consists of the variants of these fragments that are found in a particular isolate. A computer program that can identify...
Topics
- Algorithms
- Bacterial Typing Techniques
- DNA Primers
- DNA, Bacterial
- Databases, Nucleic Acid
- Genetic Variation
- Genotype
- Humans
- Kinetics
- Neisseria meningitidis