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Article

Mice immunization with live lactococci displaying a surface anchored HPV-16 E7 oncoprotein

15 Nov 2003

Abstract excerpt

E7 oncoprotein of human papillomavirus-16 (HPV-16) is constitutively produced in cervical cancer (CxCa) and is a good candidate for the design of therapeutic vaccines. In this work, the nisin-controlled expression system was used to display the E7 protein at the cell surface of the food-grade Gram-positive bacterium Lactococcus lactis. An efficient cell wall anchoring of E7 was obtained. Intranasal administration...

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PMID: 14659540
DOI: 10.1016/s0378-1097(03)00778-x

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